Top class inhalation devices

For optimized aerosolized drug inhalation, Activaero has developed a unique therapy concept called FAVORITE. The FAVORITE concept provides optimized inhalation flow and volume for patients with lung diseases. The electronically controlled inhalation is based on therapeutic and dosing requirements and can be adjusted to the patients' individual condition.

Operating with the FAVORITE technology the AKITA^® inhalation systems offer a significant quality improvement in all important points of inhalation therapy:

Drug use efficiency

With FAVORITE, the AKITA inhlation systems can electronically regulate both inspiration flow and inhalation volume. This guarantees that these parameters will always be maintained within an optimal range which ensures a save and reproducible deposition of the active agent in the lungs.

FAVORITE Inhalation - high lung deposition through the electronic control of inspiration flow and volume

: Alveolar lung deposition of 1 to 5 µm particles following inhalation using different inspiration patterns and inhalation volumes.

^{Reference: ICRP 1994; Human Respiratory Tract Model for Radiological Protection. A Report of a Task Group of the International Commission on Radiological Protection. Ann. ICRP 24, 1-482 (1994).}

Reproducibility of lung dose

Patients with lung disease generally have variable and sub-optimal breathing patterns,which can negatively affect lung deposition. FAVORITE resolves this problem - the administration of drug aerosol ensures controlled and optimized breathing. In addition to a higher deposition, FAVORITE maintains low dosage variability and exact reproducibility of the patients' daily required dose of drugs.

FAVORITE Inhalation - highly precise and low variable dosing through constantly optimized breathing

Variability of lung deposition in 18 patients with severe lung disease
after inhalation of 3 μm particles.

^{Reference: Brand et al. 2000; Total Deposition of Therapeutic Particles During Spontaneous and Controlled Breathing. Journal of Pharmaceutical Science, 2000. 89: p. 724-731.}

Pulmonary "Drug Targeting"

FAVORITE allows continuous control of both aerosolized drugs and air during the inhalation process. Pre-defined variation in the pattern of the drug and air bolus means that drug deposition can be navigated into a certain region of the lung. Depending on the drug and therapeutic goal, a drug can be deposited directly at the place of action.

For the very first time in inhaled treatment, AKITA^® Inhalation systems allow for precise "Drug Targeting"

"Drug Targeting" via continuous control of aerosolized drugs and air.

Treatment of obstructive patients

The concept of FAVORITE inhalation is based on flow and volume controlled respiration that utilizes a slide increase in pressure to guide the inhalation of the drug. The increase in pressure is often required in order to efficiently deliver the drug to less ventilated areas in the lungs, especially withregard to patients with pulmonary obstructions.

AKITA^® inhalation systems are improving the therapy of severe lunge diseases with obstructions

Scintigraphic image of lung deposition in a healthy subject and in a patient with pulmonary obstructions following drug inhalation (Black area is the swallowed drug in the stomach due to high deposition in the throat).

^{Reference: Meyer et al. 2001; Deposition von therapeutischen Aerosolen in der Lungenperipherie. Aerosole in der Inhalationstherapie, ed. G. Scheuch. Vol. 5. 2001, Dustri-Verlag Dr Karl Feistle: München. 93-100}

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